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Phase III Study of Pemetrexed in Combination With Cisplatin

Cisplatin and Pemetrexed Combination Study

Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma,Journal of Clinical Oncology, 21/14 (2003) by Vogelzang et al.

Cisplatin Study Metrics

The authors reported on results of Phase III clinical trials conducted to determine whether or not treatment with pemetrexed AND cisplatin results in greater survival time than treatment with cisplatin alone. The study examined 456 patients and involved medical facilities in Argentina, Australia, Belgium, Canada, Chile, Czech Republic, Finland, France, Germany, India, Italy, Mexico, Poland, Singapore, Slovakia, Spain, Taiwan, Turkey, United Kingdom, and United States.

Cisplatin Study Results

The results showed almost a 3 month gain in survival time for those treated with both pemetrexed and cisplatin. Additionally, the authors noted patients had far fewer adverse affects when given vitamin B12and low-dose folic acid.

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