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Treating Mesothelioma with microRNAs

A microRNA is a small molecule of RNA which plays a fundamental role in the way in which genes are expressed. The link between the reduction microRNA and cancer was first established well over a decade ago and has just become clearer as research has progressed.

Italian researchers published a report in Biomedicine and Pharmacotherapy studying the effects that powerful phytochemicals found in fruits and vegetables had on mesothelioma. Authors of the study wrote that currently “only one compound – ursolic acid found in apple peels – has been shown to regulate microRNAs in malignant mesothelioma cells.” However, the researchers remain hopeful that other compounds may also show success in regulating microRNA’s.

Dr. Abu Sayeed, an author of the study stated that “In this paper, we have introduced some dietary phytochemicals (curcumin, epigallocatechin gallate, quercetin, genistein, pterostilbene, resveratrol, capsaicin, ellagic acid, benzyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, indole-3-carbinol, 3,3′-diindolylmethane, diallyl disulphide, betulinic acid, and oleanolic acid) which have shown microRNA regulatory activities in various cancers and could regulate malignant mesothelioma microRNAs,”

The new research out of Italy is the last in a string of reports touting the benefits of regulating microRNAs through the natural compounds found in fruits and vegetables. MicroRNA regulation can help lead to reductions in tumor growth and in some cases even tumor size. These new findings give hope to the prospect of elongating mesothelioma survival times.

The Paul Law Firm advocates for victims of asbestos-related diseases. If you or a loved one is suffering from mesothelioma, call the Paul Law Firm. With over 2.5 billion dollars collected for victims of asbestos exposure, we have the knowledge and the experience to fight for you. We also understand that fighting doesn’t just happen in the courtroom. It also happens in a lab where we are fighting for a cure. Check out the Mesothelioma Research Foundation of America here.

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