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BAP1 And Mesothelioma Survival Rates

A new research paper out of Fudan China studied the link between the tumor suppressor gene BAP1 and cancer, including malignant mesothelioma. The article, published in Tumor Biology, analyzed over 21 studies which included 2,457 patients with various types of cancer.

BAP1 is a protein which helps to suppress tumors. Researchers believe that mutative iterations of the protein may help to explain why certain people exposed to asbestos manifest malignant mesothelioma while others who were exposed do not.

The study finds however that the BAP1 mutation has little correlation with actual survival rates. Surgeon and one of the study’s authors, Dr. Wang states that “Although the pooled results demonstrated that BAP1 mutation was a negative indicator of overall survival and disease-free survival, this prognostic value was only applicable to uveal melanoma and clear cell renal cell carcinoma, but not to malignant pleural mesothelioma or cholangiocarcinoma.” In fact, for mesothelioma it is possible that the mutation actually has a minimal positive impact on mesothelioma survival rates.

The Paul Law Firm advocates for victims of asbestos-related diseases. If you or a loved one is suffering from mesothelioma, call the Paul Law Firm. With over 2.5 billion dollars collected for victims of asbestos exposure, we have the knowledge and the experience to fight for you. We also understand that fighting doesn’t just happen in the courtroom. It also happens in a lab where we are fighting for a cure. Check out the Mesothelioma Research Foundation of America here.

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