Scientists Aim to Deactivate Tumor Protecting Proteins

A cell surface protein called PD-L1 cloaks cancerous tumors from the immune system. It is estimated that approximately 40% of all malignant mesothelioma patients overexpress the PD-L1 protein – meaning that the tumor is being hidden from the immune system. Australian researchers have published a study in the Journal of Thoracic Oncology which reports that the PD-L1 protein can be deactivated from the inside.

These finding are critical because overexpression of the tumor hiding protein is highly correlated with negative treatment outcomes and shorter survival times. Too much PD-L1 leads to a higher probability of a biphasic or sarcomatoid subtype diagnosis which leads to shorter survival. The average survival time when there is no overexpression of the protein is 9.2 months, more than double the 4 month average survival time of a mesothelioma patient with overexpressed PD-L1. Author of the study,

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