Phase III Study of Cisplatin With or Without Raltitrexed
Cisplatin Treatment for Mesothelioma
Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma: An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada, Journal of Clinical Oncology 23/28 (2005) by van Meerbeeck et al.
Cisplatin Clinical Trial Study
The authors report on a study of 250 patients to determine whether survival rates improve for those givencisplatin AND raltitrexed versus cisplatin alone. Raltitrexed is an antifolate (as is pemetrexed, which has been found to increase survival rate when combined with cisplatin). The study results demonstrated an improved survival rate for those given a combination of ralitrexed and cisplatin.
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